Pharmacology - Antimicrobial Drugs MOA

1. Penicillin
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

2. Ampicillin
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

3. Ticarcillin
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

4. Piperacillin
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

5. Imipenem
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

6. Aztreonam
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

7. Cephalosporins
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

8. Bacitracin
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

9. Vancomycin
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

10. Chloramphenicol
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

11. Erythromycin
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

12. Macrolides
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

13. Lincomycin
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

14. Clindamycin
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

15. Quinupristin (Streptogramins)
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

16. Dalfopristin (Streptogramins)
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

17. Aminoglycosides
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

18. Tetracyclines
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

19. Sulfonamides
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

20. Trimethoprim
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

21. Quinolones
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

22. Rifampin
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

23. Penicillin, cephalosporins, vancomycin, aminoglycosides, fluoroquinolones, metronidazole
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

24. Polymyxins
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

25. Amphotericin B
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

26. Nystatin
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

27. Fluconazole (azoles)
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown

28. Pentamidine
a) Block cell wall synthesis by inhibition of peptidoglycan cross-linking
b) Block peptidoglycan synthesis
c) Block protein synthesis at 50s ribosomal subunit
d) Block protein synthesis at 30s ribosomal subunit
e) Block nucleotide synthesis
f) Block DNA topoisomerases
g) Block mRNA synthesis
h) Bactericidal antibiotics
i) Disrupt bacterial/fungal cell membranes
j) Disrupt fungal cell membranes
k) Unknown



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1. (a) 
2. (a) 
3. (a) 
4. (a) 
5. (a) 
6. (a) 
7. (a) 
8. (b) 
9. (b) 
10. (c) 
11. (c) 
12. (c) 
13. (c) 
14. (c) 
15. (c) 
16. (c) 
17. (d) 
18. (d) 
19. (e) 
20. (e) 
21. (f) 
22. (g) 
23. (h) 
24. (i) 
25. (j) 
26. (j) 
27. (j) 
28. (k)