Neuropharmacology 2002 1. Analgesic with least potential to cross placenta and depress fetal respiration a) Merepidine b) Naloxolone c) Valproate d) Paroxetine e) Tranylcypromide (MAO-Inhibitor) 2. 25 year old male with pinpoint pupils, infrequent shallow respiration and unconscious; treat with a) Merepidine b) Naloxolone c) Valproate d) Paroxetine e) Tranylcypromide (MAO-Inhibitor) 3. Side effects include hepatotoxicity in children a) Merepidine b) Naloxolone c) Valproate d) Paroxetine e) Tranylcypromide (MAO-Inhibitor) 4. Side effects include nausea, headache and diarrhea a) Merepidine b) Naloxolone c) Valproate d) Paroxetine e) Tranylcypromide (MAO-Inhibitor) 5. Case of a man that ate cheese and drank wine and goes to the hospital with adverse effects, he was probably taking this medication a) Merepidine b) Naloxolone c) Valproate d) Paroxetine e) Tranylcypromide (MAO-Inhibitor) 6. Increases GABA a) Oxazepam b) Valproate c) Benzodiazapine d) Glativamer e) Procainamide 7. Alternative to lithium a) Oxazepam b) Valproate c) Benzodiazapine d) Glativamer e) Procainamide 8. Theory stating that you need to increase NE and serotonin in CNS to reduce a) Biogenic amine theory b) Decreases absorption of protein c) major impairment of mental and physical control d) MAC = 20 and Lambda = 0.5 e) Ionized = 90% and pH = 7.4 and MW = 6000 9. Side effects include paradoxical hyperexcitation in children a) Oxazepam b) Valproate c) Benzodiazapine d) Glativamer e) Procainamide 10. Difference between Buspirone and Diazepam ... which has delayed onset of activity a) Buspirone b) Diazepam 11. Disposition of L-Dopa a) Biogenic amine theory b) Decreases absorption of protein c) major impairment of mental and physical control d) MAC = 20 and Lambda = 0.5 e) Ionized = 90% and pH = 7.4 and MW = 6000 12. Drug used in multiple sclerosis a) Oxazepam b) Valproate c) Benzodiazapine d) Glativamer e) Procainamide 13. This drug should not be used in patients who are allergic to codeine a) Oxazepam b) Valproate c) Benzodiazapine d) Glativamer e) Procainamide 14. Effects of 1.5 blood alcohol results in a) Biogenic amine theory b) Decreases absorption of protein c) major impairment of mental and physical control d) MAC = 20 and Lambda = 0.5 e) Ionized = 90% and pH = 7.4 and MW = 6000 15. Most rapid onset identified by a) Biogenic amine theory b) Decreases absorption of protein c) major impairment of mental and physical control d) MAC = 20 and Lambda = 0.5 e) Ionized = 90% and pH = 7.4 and MW = 6000 16. Prevents relapse in alcoholics by decreasing the craving a) Naltrexone b) Clozapine c) Chlorazepine d) Valproate e) Procainamide 17. Factors that decrease CNS entry of drug a) Biogenic amine theory b) Decreases absorption of protein c) major impairment of mental and physical control d) MAC = 20 and Lambda = 0.5 e) Ionized = 90% and pH = 7.4 and MW = 6000 18. Most potent serotonin blocker a) Naltrexone b) Clozapine c) Chlorazepine d) Valproate e) Procainamide 19. Decreases apathy, a negative symptom of schizophrenia a) Naltrexone b) Clozapine c) Chlorazepine d) Valproate e) Procainamide 20. Better in tolerance when compared to lithium a) Naltrexone b) Clozapine c) Chlorazepine d) Valproate e) Procainamide 21. Atypical cholinesterase a) Naltrexone b) Clozapine c) Chlorazepine d) Valproate e) Procainamide 22. Compulsive drug use is defined as a) Biogenic amine theory b) Decreases absorption of protein c) Use of a drug despite adverse medical and social consequences d) Anesthesia (no answer provided for this question in the breakdown) e) Synaptic neurotransmitters 23. MOA: Reduces rate of Na++ channels recovery for activation a) Kentamine b) Amitriptyline c) Fluoxetine d) Bupropion e) Phenytoin 24. Drug causing least likely dependence a) LSD b) Lorazepam c) Donezepil d) Methanol e) Halothane 25. Useful for stopping active seizures (status epilepticus). Not for chronic seizure control. a) LSD b) Lorazepam c) Donezepil d) Methanol e) Halothane 26. Alzheimer's a) LSD b) Lorazepam c) Donezepil d) Methanol e) Halothane 27. Metabolizes to formic acid and formaldehyde a) LSD b) Lorazepam c) Donezepil d) Methanol e) Halothane 28. Can cause hepatitis a) LSD b) Lorazepam c) Donezepil d) Methanol e) Halothane 29. Cardio-toxic a) Buvicapine b) Chlorpramezine c) L-Dopa d) Methadone e) Carbamazepine 30. Do not use with Parkinson's patients a) Buvicapine b) Chlorpramezine c) L-Dopa d) Methadone e) Carbamazepine 31. Enduces euphoria and hallucinations a) Cocaine b) Dopamine c) Valproate d) Barbiturates e) Morphine 32. Long duration of action a) Buvicapine b) Chlorpramezine c) L-Dopa d) Methadone e) Carbamazepine 33. Anesthesia (no answer provided for this question in the breakdown) a) Biogenic amine theory b) Decreases absorption of protein c) Use of a drug despite adverse medical and social consequences d) Anesthesia (no answer provided for this question in the breakdown) e) Synaptic neurotransmitters 34. Kid with neck and facial muscles "messed up" a) Buvicapine b) Chlorpramezine c) L-Dopa d) Methadone e) Carbamazepine 35. Not a CNS transmitter a) Buvicapine b) Chlorpramezine c) L-Dopa d) Methadone e) Carbamazepine 36. MOA: works by binding of GABA a) Kentamine b) Amitriptyline c) Fluoxetine d) Bupropion e) Alcohol 37. Drugs work by acting as a) Biogenic amine theory b) Decreases absorption of protein c) Use of a drug despite adverse medical and social consequences d) Anesthesia (no answer provided for this question in the breakdown) e) Synaptic neurotransmitters 38. Works in the nucleus accumbens a) Cocaine b) Dopamine c) Valproate d) Barbiturates e) Morphine 39. Causes it's effects in the dorsal raphe nucleus a) Cocaine b) Dopamine c) Valproate d) Barbiturates e) Morphine 40. A patient with antiepileptic drug that is not working ... which other drug can you give as treatment a) Cocaine b) Dopamine c) Valproate d) Barbiturates e) Morphine 41. Hypnotic drug that produces hangover effect a) Cocaine b) Dopamine c) Valproate d) Barbiturates e) Morphine 42. Abnormal involuntary movements (dyskinesia) a) L-Dopa b) Selegiline c) Proftelone d) Carbamazepine e) Phenytoin 43. Slows Parkinson's progression by decreasing dopamine oxidation products a) L-Dopa b) Selegiline c) Proftelone d) Carbamazepine e) Phenytoin 44. Anesthetic that does not accumulate a) L-Dopa b) Selegiline c) Proftelone d) Carbamazepine e) Phenytoin 45. Associated with aplastic anemia a) L-Dopa b) Selegiline c) Proftelone d) Carbamazepine e) Phenytoin 46. Associated with gingival hyperplasia a) L-Dopa b) Selegiline c) Proftelone d) Carbamazepine e) Phenytoin 47. Withdrawal signs are NO life threat a) Heroin b) Short acting barbiturates c) Tobacco d) Entacapone e) NO 48. Withdrawal signs ARE a life threat a) Heroin b) Short acting barbiturates c) Tobacco d) Entacapone e) NO 49. Associated with abstinence syndrome a) Heroin b) Short acting barbiturates c) Tobacco d) Entacapone e) NO 50. COMT inhibitor (inactivates L-Dopa) a) Heroin b) Short acting barbiturates c) Tobacco d) Entacapone e) NO 51. Incomplete anesthetic a) Heroin b) Short acting barbiturates c) Tobacco d) Entacapone e) NO 52. Strong anesthetic a) Kentamine b) Amitriptyline c) Fluoxetine d) Bupropion e) Phenytoin 53. Blocks reuptake of norepinephrine a) Kentamine b) Amitriptyline c) Fluoxetine d) Bupropion e) Phenytoin 54. Antidepressant that blocks serotonin reuptake a) Kentamine b) Amitriptyline c) Fluoxetine d) Bupropion e) Phenytoin 55. Relieves depression by blocking dopamine reuptake a) Kentamine b) Amitriptyline c) Fluoxetine d) Bupropion e) Phenytoin ----------Key---------- 1. (a) 2. (b) 3. (c) 4. (d) 5. (e) 6. (a) 7. (b) 8. (a) 9. (c) 10. (a) 11. (b) 12. (d) 13. (e) 14. (c) 15. (d) 16. (a) 17. (e) 18. (b) 19. (c) 20. (d) 21. (e) 22. (c) 23. (e) 24. (a) 25. (b) 26. (c) 27. (d) 28. (e) 29. (a) 30. (b) 31. (a) 32. (d) 33. (d) 34. (e) 35. (c) 36. (e) 37. (e) 38. (b) 39. (e) 40. (c) 41. (d) 42. (a) 43. (b) 44. (c) 45. (d) 46. (e) 47. (a) 48. (b) 49. (c) 50. (d) 51. (e) 52. (a) 53. (b) 54. (c) 55. (d)